Search results for "insulin receptor signaling"

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Intranasal Insulin Administration to Prevent Delayed Neurocognitive Recovery and Postoperative Neurocognitive Disorder: A Narrative Review

2021

Delayed neurocognitive recovery and postoperative neurocognitive disorders are major complications of surgery, hospitalization, and anesthesia that are receiving increasing attention. Their incidence is reported to be 10–80% after cardiac surgery and 10–26% after non-cardiac surgery. Some of the risk factors include advanced age, level of education, history of diabetes mellitus, malnutrition, perioperative hyperglycemia, depth of anesthesia, blood pressure fluctuation during surgery, chronic respiratory diseases, etc. Scientific evidence suggests a causal association between anesthesia and delayed neurocognitive recovery or postoperative neurocognitive disorders, and various pathophysiologi…

intranasal insulinHealth Toxicology and Mutagenesismedicine.medical_treatmentNeurocognitive Disorderslcsh:MedicineReviewBioinformaticsNeuroprotection03 medical and health sciences0302 clinical medicine030202 anesthesiologyDiabetes mellitusmedicineAnimalsHumansInsulinAnesthesiaPostoperative PeriodMemory DisordersbiologyInsulin receptor signaling pathwaybusiness.industrypostoperative cognitive dysfunctionInsulinlcsh:RPublic Health Environmental and Occupational HealthPerioperativemedicine.diseaseInsulin receptorbiology.proteinneuroprotectionbusinessNeurocognitivePostoperative cognitive dysfunction030217 neurology & neurosurgeryInternational Journal of Environmental Research and Public Health
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IRS-2 deficiency impairs NMDA receptor-dependent long-term potentiation

2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.-- et al.

medicine.medical_specialtyPatch-Clamp TechniquesCognitive Neurosciencemedicine.medical_treatmentBlotting WesterneducationHippocampusComputingMilieux_LEGALASPECTSOFCOMPUTINGNeurotransmissionBiologyHippocampusReceptors N-Methyl-D-AspartateSynaptic TransmissionMiceCellular and Molecular NeuroscienceInternal medicinemedicineAnimalsImmunoprecipitationlong-term potentiationMice Knockoutsynaptic plasticitydiabetesInsulinDiabetesLong-term potentiationArticlesNMDA receptorIRS2insulin receptor signalingSynaptic fatigueEndocrinologynervous systemSynaptic plasticityInsulin Receptor Substrate ProteinsNMDA receptorFemaleNeuroscienceCerebral Cortex
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